Differential Diagnosis of Hepatosplenomegaly

Dr Ameer Khalid

Acromegaly … enlarged spleen, enlarged liver
Autoimmune Hepatitis … enlarged liver
Autoimmune Lymphoproliferative Syndrome … enlarged spleen, enlarged liver
Autoimmune Thrombocytopenia … enlarged spleen
Brucellosis … enlarged spleen, enlarged liver
Chagas disease … Hepatosplenomegaly

• Chronic Granulomatous Disease … enlarged spleen, enlarged liver
• Chronic Hepatitis C … Enlarged spleen, Enlarged liver
• Cirrhosis of the liver … Enlarged spleen, Enlarged liver
• Classic galactosemia … enlarged liver
• Common Variable Immunodeficiency … enlarged spleen
• Congenital syphilis … swollen liver, swollen spleen
• Congenital Toxoplasmosis … enlarged spleen, enlarged liver
• Cystic Fibrosis … enlarged spleen, enlarged liver
• Gaucher Disease … spleen enlargement, liver enlargement, liver enlargement, liver enlargement
• Hepatoma … enlarged spleen
• Hyper-IgM Syndrome … enlarged spleen, enlarged liver
• Infantile Refsum Disease … hepatomegaly (enlargement of the liver)
• Leishmaniasis … enlarged spleen, enlarged liver
• Leukemia … Swollen liver, Swollen spleen
• Liver abscess … enlarged liver
• Liver cancer … enlarged liver
• Lupus … enlarged spleen
• Lymphoma … enlarged spleen, enlarged liver
• Malaria … Splenomegaly, Hepatomegaly
• Mononucleosis … enlarged spleen, enlarged liver
• Mucopolysaccharidosis VII … spleen enlargement, liver enlargement
• Neonatal ALD … hepatomegaly (enlarged liver)
• Niemann-Pick disease … spleen enlargement, liver enlargement
• Non-Hodgkin’s Lymphoma … enlarged spleen, enlarged liver
• Polycythemia … enlarged spleen, enlarged liver
• Portal hypertension … enlarged spleen
• Relapsing fever … enlarged spleen, enlarged liver
• Reye’s Syndrome … enlarged liver
• Right heart failure … enlarged liver
• Schistosomiasis … enlarged liver, hepatosplenomegaly
• Sickle Cell Anemia … enlarged spleen, enlarged liver
• Systemic Juvenile Rheumatoid Arthritis … enlarged spleen
• Thalassemia … mild spleen enlargement, spleen enlargement, liver enlargement
• Thrombocytopenia … enlarged spleen
• Toxocariasis … Enlarged spleen, Enlarged liver
• Typhoid fever … splenomegaly, enlarged liver
• Vitamin A overdose … enlarged spleen, enlarged liver
• Weil’s syndrome … hepatomegaly
• Wilson’s Disease … swollen liver, swollen spleen
• Zellweger Syndrome … enlarged liver