{"id":59005,"date":"2025-01-23T05:35:11","date_gmt":"2025-01-23T05:35:11","guid":{"rendered":"https:\/\/www.homeobook.com\/?p=59005"},"modified":"2025-01-23T05:37:38","modified_gmt":"2025-01-23T05:37:38","slug":"a-review-on-ankylosing-spondylitis-and-homoeopathy","status":"publish","type":"post","link":"https:\/\/www.homeobook.com\/a-review-on-ankylosing-spondylitis-and-homoeopathy\/","title":{"rendered":"A review on Ankylosing Spondylitis and Homoeopathy"},"content":{"rendered":"

Dr Jainish M Malaviya<\/strong><\/p>\n

Abstract
\n<\/strong>AS is present in 1% to 6% of adults inheriting HLA-B27. Ankylosing spondylitis (AS) is an inflammatory condition. Predominant clinical feature of AS is inflammatory backache followed by stiffness of the spine.\u00a0(1)<\/sup><\/p>\n

Keywords
\n<\/strong>Ankylosing Spondylitis (AS), Sacroiliitis, HLA-B27, Enthesopathy, Spondyloarthropathies (SpA).<\/p>\n

Introduction
\n<\/strong>AS is symptomatic sacroiliitis (persistent pain and stiffness for >3 months associated with morning stiffness and improvement with exercise\/worsening with rest).\u00a0(2)<\/sup><\/p>\n

Epidemiology of AS
\n<\/strong>Epidemiology AS is present in 1% to 6% of adults inheriting HLA-B27, whereas the prevalence is 10% to 30% among HLA-B27+ adult first degree relatives. In whites, the prevalence of AS is 0.5% to 1% and male to female ratio is 5:1. The HLA-B27 is found in 90% to 95% of patients. There are no Indian data on prevalence of AS. Positivity of HLA-B27 in studies from north and south India is 94% and 83%, respectively.\u00a0(1)<\/sup><\/p>\n

Pathogenesis of AS
\n<\/strong>There is a persistent inflammation at the affected synovial joints and entheseal sites with increased mononuclear cell infiltrates. Participation of both macrophages and T cells in an inflammatory 1845 process triggered by a yet undefined antigen presented by susceptible HLA molecules is believed to be fundamental to the pathogenic process. The strong association of HLA-B27 in all ethnic groups suggests a predominant role for this class I molecule. The HLA-B27 has 29 subtypes and B2704 and B2705 are susceptible and B2706 and B2709 are non-susceptible subtypes. Certain environmental microbial factors interplay with susceptible genes to trigger off the immune-mediated synovitis. However, the link between any particular microbe with AS is weak.\u00a0(1)<\/sup><\/p>\n

Clinical features of AS<\/strong><\/p>\n