{"id":8840,"date":"2012-05-25T00:17:29","date_gmt":"2012-05-25T00:17:29","guid":{"rendered":"http:\/\/www.homeobook.com\/?p=8840"},"modified":"2021-08-14T02:08:56","modified_gmt":"2021-08-14T02:08:56","slug":"modulation-of-signal-proteins-how-potentised-homeopathy-act","status":"publish","type":"post","link":"https:\/\/www.homeobook.com\/modulation-of-signal-proteins-how-potentised-homeopathy-act\/","title":{"rendered":"Modulation of Signal Proteins \u2013 How potentised homeopathy act"},"content":{"rendered":"<p style=\"text-align: justify;\"><strong>Modulation of Signal Proteins: A Plausible Mechanism to Explain How a Potentized Drug Secale Cor 30C Diluted beyond Avogadro&#8217;s Limit Combats Skin Papilloma in Mice<\/strong><\/p>\n<p style=\"text-align: justify;\">Anisur Rahman Khuda-Bukhsh1, Soumya Sundar Bhattacharyya1, Saili Paul1, Suman Dutta1, Naoual\u00a0 Boujedaini2 and Philippe Belon2<\/p>\n<p style=\"text-align: justify;\">1Cytogenetics and Molecular Biology Laboratory, Department of Zoology, University of Kalyani, Kalyani 741235, West Bengal, India and 2Boiron Laboratory, Lyon, France<br \/>\n<strong><br \/>\nIn homeopathy,<\/strong> ability of ultra-high diluted drugs at or above potency 12C (diluted beyond Avogadro&#8217;s limit) in ameliorating\/curing various diseases is often questioned, particularly because the mechanism of action is not precisely known. We tested the hypothesis if suitable modulations of signal proteins could be one of the possible pathways of action of a highly diluted homeopathic drug, Secale cornutum 30C (diluted 1060 times; Sec cor 30). It could successfully combat DMBA + croton oil-induced skin papilloma in mice as evidenced by histological, cytogenetical, immunofluorescence, ELISA and immunoblot findings.<\/p>\n<p style=\"text-align: justify;\">Critical analysis of several signal proteins like AhR, PCNA, Akt, Bcl-2, Bcl-xL, NF-kB and IL-6 and of pro-apoptotic proteins like cytochrome c, Bax, Bad, Apaf, caspase-3 and -9 revealed that Sec cor 30 suitably modulated their expression levels along with amelioration of skin papilloma. FACS data also suggested an increase of cell population at S and G2 phases and decrease in sub-G1 and G1 phages in carcinogen-treated drug-unfed mice, but these were found to\u00a0 be near normal in the Sec cor 30-fed mice.<\/p>\n<p style=\"text-align: justify;\">There was reduction in genotoxic and DNA damages in bone marrow cells of Sec Cor 30-fed mice, as revealed from cytogenetic and Comet assays. Changes in histological features of skin papilloma were noted. Immunofluorescence studies of AhR and PCNA also suggested reduced expression of these proteins in Sec cor 30-fed mice, thereby showing its anti-cancer potentials against skin papilloma. Furthermore, this study also supports the hypothesis that potentized homeopathic drugs act at gene regulatory level.<br \/>\n<strong><br \/>\nKeywords:<\/strong> aryl hydrocarbon receptor \u2013 Avogadro&#8217;s number \u2013 cytogenetic damage \u2013 gene expression \u2013 immunoblot \u2013 immunofluorescence \u2013 potentized homeopathic drug \u2013 signal proteins \u2013 skin papilloma<\/p>\n<p><strong>Read full article at<\/strong> : <a href=\"http:\/\/www.homeobook.com\/pdf\/research161.pdf\">http:\/\/www.homeobook.com\/pdf\/research161.pdf<\/a>\u00a0<strong>\u00a0 <\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<div class=\"mh-excerpt\"><p>Modulation of Signal Proteins: A Plausible Mechanism to Explain How a Potentized Drug Secale Cor 30C Diluted beyond Avogadro&#8217;s Limit Combats Skin Papilloma in Mice Anisur Rahman Khuda-Bukhsh1, Soumya Sundar Bhattacharyya1, Saili Paul1, Suman Dutta1, <a class=\"mh-excerpt-more\" href=\"https:\/\/www.homeobook.com\/modulation-of-signal-proteins-how-potentised-homeopathy-act\/\" title=\"Modulation of Signal Proteins \u2013 How potentised homeopathy act\">[&#8230;]<\/a><\/p>\n<\/div>","protected":false},"author":1,"featured_media":42206,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[41],"tags":[2075],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Modulation of Signal Proteins \u2013 How potentised homeopathy act<\/title>\n<meta name=\"description\" content=\"Modulation of Signal Proteins: A Plausible Mechanism to Explain How a Potentized Drug Secale Cor 30C Diluted beyond Avogadro&#039;s Limit Combats Skin Papilloma in Mice\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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